What happens if you overdose?

From Desk Reference to the Diagnostic Criteria from DSM-3-R (American Psychiatric Association, 1987):

Caffeine-Induced Organic Mental Disorder 305.90 Caffeine Intoxication

  1. Recent consumption of caffeine, usually in excess of 250 mg.
  2. At least five of the following signs:
    1. restlessness
    2. nervousness
    3. excitement
    4. insomnia
    5. flushed face
    6. diuresis
    7. gastrointestinal disturbance
    8. muscle twitching
    9. rambling flow of thought and speech
    10. tachycardia or cardiac arrhythmia
    11. periods of inexhaustibility
    12. psychomotor agitation
  3. Not due to any physical or other mental disorder, such as an Anxiety Disorder.

Basically, overdosing on caffeine will probably be very very unpleasant but not kill or deliver permanent damage. However, People do die from it.

Toxic dose

The LD_50 of caffeine (that is the lethal dosage reported to kill 50% of the population) is estimated at 10 grams for oral administration. As it is usually the case, lethal dosage varies from individual to individual according to weight. Ingestion of 150mg/kg of caffeine seems to be the LD_50 for all people. That is, people weighting 50 kilos have an LD_50 of approx. 7.5 grams, people weighting 80 kilos have an LD_50 of about 12 grams.

In cups of coffee the LD_50 varies from 50 to 200 cups of coffee or about 50 vivarins (200mg each).

One exceptional case documents survival after ingesting 24 grams. The minimum lethal dose ever reported was 3.2 grams intravenously, this does not represent the oral MLD (minimum lethal dose).

In small children ingestion of 35 mg/kg can lead to moderate toxicity. The amount of caffeine in an average cup of coffee is 50 - 200 mg. Infants metabolize caffeine very slowly.

 

Symptoms
  • Acute caffeine poisoning gives early symptoms of anorexia, tremor, and restlessness. Followed by nausea, vomiting, tachycardia, and confusion. Serious intoxication may cause delirium, seizures, supraventricular and ventricular tachyarrhythmias, hypokalemia, and hyperglycemia.
  • Chronic high-dose caffeine intake can lead to nervousness, irritability, anxiety, tremulousness, muscle twitching, insomnia, palpitations and hyperreflexia. For blood testing, cross-reaction with theophylline assays will detect toxic amounts. (Method IA) Blood concentration of 1-10 mg/L is normal in coffee drinkers, while 80 mg/L has been associated with death.
Treatment
  • Emergency Measures
    • Maintain the airway and assist ventilation. (See Appendix A)
    • Treat seizures & hypotension if they occur.
    • Hypokalemia usually goes away by itself.
    • Monitor Vital Signs.
  • Specific drugs & antidotes. Beta blockers effectively reverse cardiotoxic effects mediated by excessive beta-adrenergic stimulation. Treat hypotension or tachyarrhythmias with intravenous propanolol, .01 - .02 mg/kg. , or esmolol, .05 mg/kg , carefully titrated with low doses. Esmolol is preferred because of its short half life and low cardioselectivity.
  • Decontamination
    • Induce vomiting or perform gastric lavage.
    • Administer activated charcoal and cathartic.
    • Gut emptying is probably not needed if 1 2 are performed promptly.
Appendix A
Performing airway assistance.
  1. If no neck injury is suspected, place in the "Sniffing" position by tilting the head back and extending the front of the neck.
  2. Apply the "Jaw Thrust" to move the tongue out of the way without flexing the neck: Place thumb fingers from both hands under the back of the jaw and thrust the jaw forward so that the chin sticks out. This should also hurt the patient, allowing you to judge depth of coma. :)
  3. Tilt the head to the side to allow vomit and snot to drain out.

From conversations on alt.drugs.caffeine:

The toxic dose is going to vary from person to person, depending primarily on built-up tolerance. A couple people report swallowing 10 to 13 vivarin and ending up in the hospital with their stomaches pumped, while a few say they've taken that many and barely stayed awake.

A symptom lacking in the clinical manual but reported by at least two people on the net is a loss of motor ability: inability to move, speak, or even blink. The experience is consistently described as very unpleasant and not fun at all, even by those very familiar with caffeine nausea and headaches.

Comments

Green Stingers

I ordered some of these off the internet over a year ago. They have ephedra and caffeine in them. I'd taken Metabolife prior to it being outlawed and I enjoyed the burst of energy it gave me and how alert I felt so when I found out ephedra was legalized again I decided to find some I could take. When I got them I took just one a few times but it made me feel weird so I quit taking them.

A couple months ago I started working with a personal trainer. When I started working out on my own I realized I was having a hard time being motivated enough to wake up and go to the gym. One morning I remembered the Green Stingers. I took two of them. Stupidly I also drank two cups of coffee. When I got to work the office was very cold so I drank a cup of hot green tea. Well, about an hour later one of my coworkers was in my office talking to me and this horrible feeling came over me - it felt like my heart was trying to burst out of my chest, I had a cold, tight feeling on the left side of my chest and my thoughts were racing like crazy. I stood up and shoved past my coworker and started pacing the hall - then I went to the lobby of the building and started walking in circles around the perimeter. My palms were clammy and I felt like I couldn't catch my breath. At one point my office manager came out and asked me if I was okay and I told her I felt like I was having a panic attack. She told me to go outside, maybe the fresh air would help.

I spent the next two hours walking almost non-stop. And praying. I thought I was going to die - seriously. I kept going back and forth over whether or not to ask my coworkers to call an ambulance. I kept trying to calm myself down by meditating and focusing on slowing my breathing. Every time I would consider going back in to the office I would get that horrible hot/cold, tight feeling in my chest and would think I was going to pass out. The thought of having to speak to anyone made me want to puke. I couldn't make eye contact with anyone. It was hands down the scariest, most horrible feeling I've ever experienced in my life. At some point I remembered I had one Xanax in my desk drawer so I finally worked up the nerve to go in and take it. Then I walked some more. Then I drank FOUR cups of Tension Tamer tea. I drank a lot of water and I ate a good lunch. I did not start feeling somewhat back to normal until the next day.

Needless to say as soon as I got home that night I threw the rest of the bottle away. I will NEVER take that stuff again!

Omg! I couldn't stop laughing

Omg! I couldn't stop laughing at your story! I felt similar though,  just went to the doctor and he said everything is fine. I think I od on coffee I never drink but had 4 cups 2days ago. I thought I was going to die started feeling weird 30 mins after 4th cup. Extremely sick to my stomach,  had a panic attack at the gas station too scared to get on the freeway to go home. Since then feeling faint,  tingling skin,  headache, fatigue,  chest pains.  Worst then drugs, never again! 

I think this is retarted aye

Heyy every 1 ,,

i realy dont see how yu can over dose on caffine aye ive eaten like 24 no doez in 1 hit and washed it down with a 4 pack of red bull and i get nout??

i rember when i was a bit younger i used to have maby 2 no doez and id be off ma trolley it would be wonderfull but now i just cant get that anymore i realy dont think caffine can get yu like use are describing.

sometimes when i have a couple red bulls my heart rate inccreases but only for a couple of minuets maby an hour but never like it used to.

please replie and tell me wot yuse think

also email me at [email protected] and yu can add me on msn 2 if yuu wanna chat about it

You seem to have suffered

You seem to have suffered quite a severe brain injury from your caffeine related exploits, as your spelling and grammar abilities appear to have been almost completely expunged from your mind!

You sound like you do not

You sound like you do not like yourself and in need of growing up! The best highs come naturally. Try going for a swim. You might discover something enlightening.

lol i disagree

lol i disagree

Caffine Overdose.

I recently experienced this. Actually just 3 days ago and am still feeling the effects of it. I had a major overdose, I had taken two caffine pills and had a couple of cups of coffee as well. I went and worked out breaking down the pills way to quickly and it sent me into a panic or anxiety attack. I had an extreme rapid heart rate, my breathing was uncontrollable, I was shaking very badly, I also had sharp pains in the back of my head, and a major feeling of my head being completely detached from my body ( I could not feel anything from my neck down no matter how much pressure I put on it). Since I have been out of the hospital I haven't slept but only a few hours over the past few days and I've been having a lot of trouble breathing at night, as if my airway closes up when my breathing slows and I also experience that same detached feeling from my body almost as if I were paralyzed. It is a very scary feeling and I'm hoping that since I've cut out the caffeine that maybe the symptoms will slowly get better. But, reality is this you really have to watch what your doing with caffeine it can kill you if you are not careful with it. I was happy to find this information on here, it does give me some enlightenment to what all is going on with me right now. It helps me much more than any of the doctors at my closest hospital. Thank you for posting thid it is very much appreciated!

Caffeine

hi, i have been doing some research on this stuff and if you drink a good enough amount you can have a heart attack and might even have a stroke. You blood pressure will rise or even go down. You want to drink lots of water. Hope Everything is well!

overdose

Hi, there i'm actually getting the same symptoms as described.... or part of them... i drank five cups of expresso all while working... so what i would like to know is to what extent can these five cups harm me? Tho, i felt like drunk during the day. i can neither eat, neither sleep, i'm over-excited.. lol... and i'm afraid...:S... so can someone please help me? thanks.

side effects

You are at a high rish for a heart attack and a strok. Your blood pressure will rise and or go down. You will want more sugar and you will be excited for a while. Just try drinking lots of water and do eat. This will help the cause of everything!

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